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Preview: San Francisco 49ers vs Arizona Cardinals — Sep 27

The San Francisco 49ers are set to take on the Arizona Cardinals in an upcoming NFL matchup scheduled for Sunday, September 27, 2026, at 8:05 PM UTC.

Heading into this contest, the 49ers hold a 2-0 record and currently sit as the fifth seed in the National Football Conference. Meanwhile, the Cardinals look to improve their standing with a 1-1 record, placing them 13th in the conference hierarchy.