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Ohio State vs. Indiana odds, picks, predictions, line: Betting preview for college football Week 7 on Saturday

Top-five college football programs Ohio State and Indiana are preparing for a Week 7 showdown on Saturday afternoon at Memorial Stadium in Bloomington. The reigning national champions from Indiana enter this matchup undefeated, whereas the visiting Buckeyes look to continue their dominant run following a single close defeat earlier in the season.

Bookmakers have installed Ohio State as small favorites in a contest that also marks the one-hundredth iteration of their historic series. Both head coaches bring exceptionally high career winning percentages into this clash, while star wide receiver Jeremiah Smith approaches a conference touchdown milestone amid his Heisman campaign.

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