NFL

NFL Week 5 gambling preview: Bet on Trevor Lawrence, plus other picks

October 11, 2026

Trevor Lawrence’s Week 5 matchup against the Philadelphia Eagles presents a compelling betting opportunity, particularly on his rushing yardage. Despite the Jaguars’ roster struggles, Lawrence’s ability to extend plays on the ground could shine against a defensive front that has forced opposing quarterbacks into high-run rates this season.

With four games already seeing quarterbacks rush 16 times against Philly’s defense, Lawrence’s mobility could prove decisive—making the over/under 14.5 rushing yards a strong wager at -110 odds. Elsewhere, the Cincinnati Bengals and Seattle Seahawks both face favorable matchups, with Cincinnati targeting the Miami Dolphins (ranked among the league’s worst) and Seattle aiming to curb the San Francisco 49ers’ recent overinflated dominance.

The Seahawks’ +106 moneyline offers a high-risk, high-reward play, while Jayden Daniels’ return to the Washington Commanders’ lineup opens another betting angle: his track record of 30+ rushing yards in 77% of his games suggests another strong showing could be in store against the Giants. Rookie Jeremiyah Love also stands out, with his consistent receiving out of the backfield—11 catches in four games—positioning him well against the Detroit Lions’ pass-heavy defense, which ranks last in passes completed and first downs allowed.