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NFL odds, betting, storylines: 2 underdogs to back in Week 6

After a strong run of underdog picks in the early weeks of the 2026 NFL season, the trend has cooled—but two overlooked teams offer compelling betting opportunities in Week 6. The Houston Texans, who had not won a game or covered a spread since December 2025, snapped their losing streak in Week 5 with a dominant 26-3 victory over the winless Tennessee Titans.

Now, they head to London for a rematch with the red-hot Jacksonville Jaguars, who have won 12 of their last 13 games and covered the spread in 11 of those contests. Despite Jacksonville’s recent form, the Texans are slight underdogs (-2.5), a mismatch that could favor Houston, especially after their first road win of the season.

Meanwhile, the Los Angeles Chargers, mired in a 0-5 start and without a win or spread cover since October 2025, face the 4-0 Kansas City Chiefs. The Chargers’ offense, led by a quarterback with the league’s second-worst rating, has scored fewer points than all but two other teams, while their roster remains battered by injuries.

With the Chiefs fresh off a bye, the Chargers’ underdog status (-8.5) presents another high-risk, high-reward opportunity for bettors.

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