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NFL Injury Report, Week 4: Latest news, updates on Justin Jefferson, De'Von Achane more for fantasy football

The 2026 fantasy football landscape has suffered heavy blows following a rash of major Week 3 injuries. Miami running back De'Von Achane was diagnosed with a torn ACL that will force him to miss the remainder of the season, leaving Ollie Gordon II and Jaylen Wright to handle backfield duties.

Meanwhile, Tampa Bay quarterback Baker Mayfield sustained a dislocated right thumb during a loss to the Vikings, putting his availability in jeopardy alongside fellow signal-callers Caleb Williams, Jayden Daniels, and Jaxson Dart.

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NFL Week 4 injury report: Justin Jefferson out, Nico Collins in; Terry McLaurin suffers late-week injury