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Week 2 of the 2026 NFL campaign begins on Thursday, September 17, with a primetime contest between the Detroit Lions and the Buffalo Bills. Both squads carry matching 1-0 records into the showdown, having each secured a victory by a single score during their respective season openers.
Streaming coverage for the interconference clash is broadcast on Amazon Prime.
The matchup also marks a historic milestone for the host franchise, serving as the inaugural regular-season fixture held at the newly constructed Highmark Stadium. Opposing quarterbacks Jared Goff and Josh Allen square off as Detroit travels to Orchard Park for the facility's competitive debut.
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