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Jaguars vs. Bengals odds, picks, prediction, spread, line: Start time, preview, best bets for NFL Week 4

The Jacksonville Jaguars travel to Ohio for a Week 4 matchup against the Cincinnati Bengals during the 2026 NFL season. DraftKings Sportsbook has installed the home team as 2.5-point favorites with an over/under set at 51.5 points.

Cincinnati quarterback Joe Burrow is fully healthy for this meeting, unlike a previous encounter last year when he sustained an injury. Kickoff is scheduled for 1 p.m.

Eastern time. The SportsLine Projection Model has simulated the contest 10,000 times, continuing a strong multi-year run on its top-rated selections.

Jacksonville arrives following a commanding 35-6 victory over New England where quarterback Trevor Lawrence threw three touchdowns and the defense forced three turnovers against Drake Maye.

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