Photo by Tennessee Titans (CC BY 3.0), via Wikimedia Commons

Chargers vs. Arizona Cardinals: How to watch, start time, odds and prediction

The Los Angeles Chargers host the Arizona Cardinals at SoFi Stadium on Sunday, September 13, to launch their 2026 campaign. Los Angeles enters the Week 1 clash heavily favored following back-to-back 11-victory campaigns, whereas Arizona managed only a 3-14 mark a year ago and searches for just its second road triumph over the franchise dating back to 2001.

The matchup also presents an offensive line health concern for the visitors.

Spotlights will shine brightly on quarterback Justin Herbert as he runs an attack newly coordinated by Mike McDaniel, bolstered by tackle Rashawn Slater alongside weapons Omarion Hampton and Ladd McConkey. Meanwhile, Arizona brings its own offensive threats into the showdown, notably tight end Trey McBride, amidst broader restructuring across the franchise.