
The Arizona Cardinals launched the Mike LaFleur era with a stunning 26-14 road upset over Jim Harbaugh and the Los Angeles Chargers at SoFi Stadium. Tight end Trey McBride helped seal the outcome by reaching the end zone on a fourth-quarter touchdown catch.
Arizona entered the matchup as the league's largest Week 1 underdog after enduring an injury-plagued three-win campaign the year prior, but the squad managed to snap a losing skid that dated back to November 3, 2025.
With the season-opening triumph, LaFleur became the franchise's first non-interim head coach to claim victory in his inaugural game since Don Coryell accomplished the feat back in 1973. The former Los Angeles Rams assistant, who also logged numerous coaching stops in both college football and the professional ranks, effectively halted a 53-year franchise dry spell on his way to his first career head coaching win.
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