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Week 4 NFL odds, picks, predictions: Computer model backs Giants and Seahawks

As the NFL prepares for its final full slate of sixteen matchups before the bye weeks begin, the league will host its first international fixture of the year in London. The Indianapolis Colts enter that overseas contest against the Washington Commanders as three-and-a-half-point favorites.

Meanwhile, a computer simulation model has processed thousands of iterations for the Week 4 schedule, highlighting several key point spreads across upcoming divisional games. In other matchups, the New Orleans Saints prepare to face the Atlanta Falcons during an anniversary weekend, while heavy point spreads favor squads like the Baltimore Ravens and Minnesota Vikings against winless opponents.

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