Photo via CBS Sports

Week 2 NFL odds, picks, predictions: Computer model backs Seahawks and Buccaneers

Following an international appearance in Australia during opening week, the Rams and 49ers will both stay stateside with home fixtures in Week 2. 5 points, representing the widest point spread across the league so far this year.

5-point favorite, marking one of six contests throughout the slate featuring a spread of seven points or more.

SportsLine's analytical computer system, which runs 10,000 simulations per contest, has determined its selections for the entire round of action. The system holds a 53-39 record on its highest-rated recommendations since 2024, earning over $7,000 for standard $100 bettors over its lifespan.

5 points.