Photo via CBS Sports

Week 2 2026 bold predictions: Giants to upset Rams, tanking Dolphins cover against 49ers

Week 1 delivered major shakeups, featuring Arizona's 26-14 road victory over the Los Angeles Chargers and San Francisco's 27-7 rout of the Los Angeles Rams in Australia. Buffalo then launched Week 2 by christening their brand-new Highmark Stadium with a 41-31 triumph against Detroit after racing out to an early 21-point cushion.

Hurt by the absences of safeties Brian Branch and Kerby Joseph, the Lions became just the second roster in franchise history to yield over 70 points and 900 yards across their initial two outings, matching their winless 2008 campaign.

0-point scoring average versus the New York Giants into a projected upset loss against John Harbaugh's squad. A defeat would make the Rams merely the fifth preseason Super Bowl favorite over the past half-century to stumble to an 0-2 start, joining the 1987 Giants, 1993 Cowboys, 2002 Rams, and 2015 Seahawks.

New York enters the matchup following a 28-20 opening win over Dallas, a contest where they stifled Dak Prescott, , and George Pickens by converting 9 of 11 third downs and dominating possession time 36:40 to 23:20 behind quarterback Jaxson Dart.