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Ohio State vs. Iowa odds, betting preview: Picks, predictions for Big Ten college football showdown

The unbeaten Iowa Hawkeyes prepare for a major conference clash this weekend as they welcome the fourth-ranked Ohio State Buckeyes to their home turf. Fourth-ranked Ohio State enters this matchup holding a three-win, one-loss record following an early-season setback against Texas, though they boast a potent offense led by quarterback Julian Sayin and star receiver Jeremiah Smith.

Iowa secured momentum in their conference opener by edging past Michigan on a last-second score, giving them a four-win, zero-loss start ahead of Saturday afternoon's kickoff.

Bookmakers currently list the visiting Buckeyes as heavy favorites by nearly fifteen points for the Week 5 contest, with the over-under total set around mid-forties. The Hawkeyes will be forced to navigate this difficult test without two defensive backs, Tyler Brown and Kyler Gerardy, both ruled out due to injuries.

Kickoff is scheduled for mid-afternoon Eastern time as Ohio State looks to continue its historical dominance in this head-to-head series.

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