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Lions vs. Bills odds, predictions, NFL picks, best bets: Betting preview for Thursday Night Football

Week 2 of the NFL calendar opens with a Thursday night clash between the Buffalo Bills and Detroit Lions at Highmark Stadium in Orchard Park, New York. Since 2023, both franchises share the league's top record at 37-15 alongside the Philadelphia Eagles.

5, having taken five straight head-to-head encounters against Detroit, including a high-scoring 48-42 triumph in 2024. Buffalo boasts an 18-2 record across its previous 20 home contests and launched the season by edging the Houston Texans 36-31, though defensive back Cole Bishop is designated questionable due to knee and groin issues.

Detroit arrives following a tight 31-30 overtime victory over the New Orleans Saints in Week 1, carrying an impressive 14-3 record in primetime matchups over the past five campaigns. When these squads previously crossed paths, Josh Allen produced 430 combined yards with four touchdowns, while Jared Goff threw for 494 yards and five scores.