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Week 5 NFL odds, picks, predictions: Computer model backs Vikings and Bengals

The SportsLine predictive algorithm has completed 10,000 simulations for the Week 5 NFL slate. The model, which has maintained a profitable track record since 2024, is currently highlighting betting opportunities across several matchups, including the Seahawks hosting the 49ers as 3-point favorites.

Other notable spreads feature the Bengals favored by 7 points over the Dolphins, while the Texans and Titans face off as winless teams. Additional games on the schedule include the Steelers against the Colts and the Lions versus the Cardinals.

The Sunday night finale features the Falcons as 3-point favorites against the Ravens, who will be playing without their starting quarterback due to an ankle injury.

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