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USC vs. Penn State prediction, odds, pick for pivotal showdown in Week 6

The USC Trojans (5-1, 3-1 in the Big Ten) face a critical road test at Penn State this Saturday, aiming to bounce back from their lone loss of the season—a home upset by Oregon. With a win in Happy Valley, USC could extend Penn State’s losing streak and gain valuable momentum ahead of a brutal stretch against Wisconsin, Ohio State, and Indiana.

Meanwhile, Penn State (3-2, 0-2) seeks to break out of a two-game skid and avoid a repeat of last season’s six-game slide, which left the Nittany Lions with a losing record. Quarterback Rocco Becht will be under intense pressure to deliver, as USC’s explosive offense, led by Jayden Maiava, poses a major challenge after Penn State’s defense struggled against Northwestern’s ground game last week.

The matchup carries extra weight after Penn State’s 33-30 overtime victory in their last meeting in 2024, though USC holds the edge in their four previous matchups since 2000. Both teams have shown inconsistency against the spread this season, with USC going 0-1 on the road and Penn State managing just two home wins against the spread.

Injuries further complicate matters, as USC deals with key absences like wide receiver Corey Simms and safety Kendarius Reddick, while Penn State’s defense—already shaky—must account for losses including star cornerback Joshua Johnson and multiple linemen.

Up nextCollege Football· 8h ago

Penn State is College Football’s biggest disappointment & it’s Notre Dame’s fault