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NFL Week 6 picks, odds, best bets: Panthers capitalize on Eagles' troubles, Rams dominate Cardinals

The NFL’s Week 6 predictions delivered a strong showing, with a 9-6 record against the spread and an 11-4-1 straight-up mark, tying for the best weekly performance among CBS Sports analysts. While the overall season-to-date record stands at 37-41-1 against the spread, the recent uptick offers a glimmer of hope after a challenging stretch.

Last week’s picks saw standout wins, including the Pittsburgh Steelers covering against the Indianapolis Colts and the Cincinnati Bengals dominating the Miami Dolphins, though the Cleveland Browns and Jacksonville Jaguars fell short in mismatches. This week’s top targets include the Houston Texans, who are riding momentum after their first-ever win over the Tennessee Titans and a key trade for Marvin Harrison Jr., reuniting him with quarterback C.J.

Stroud. The Texans face the Jaguars in London, a team that struggled in the red zone against the Philadelphia Eagles last week, while the New England Patriots look to extend their home dominance over the New York Jets, boasting a 10-1 record in recent matchups at home and a strong defensive front featuring rookie Gabe Jacas and Elijah Moore.

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