NFL Week 6 picks and score predictions: Seahawks destroy Broncos, Eagles lose again, Cowboys stun Packers

October 13, 2026

The NFC East’s Week 5 collapse reached historic levels, with four head coaches potentially facing the same-day firing threat—a scenario that has never happened before in the league. The Cowboys suffered a humiliating loss to the Tampa Bay Buccaneers, a team with zero wins entering the game and starting an undrafted rookie quarterback.

Meanwhile, the Philadelphia Eagles squandered a late field-goal lead to lose to the Jacksonville Jaguars, while the Washington Commanders and New York Giants settled for a tie after a missed field-goal opportunity in overtime. The division’s collective meltdown set the stage for Week 6, where the Seattle Seahawks are favored to dismantle the Denver Broncos in a clash of two embattled coaching staffs, Mike Macdonald and Sean Payton, whose rivalry has only intensified following a controversial hot-mic incident earlier this year.

Macdonald’s first game as a head coach came against Payton’s Broncos in Week 1, and tensions flared when Macdonald reportedly used social media to scout Denver’s plays due to limited film. Payton’s reaction to the strategy further escalated the feud, adding another layer of intrigue to Thursday’s matchup.

With the NFC East in shambles and the Seahawks looking to capitalize, Week 6 could deliver a statement win for Seattle while the division’s other teams continue their downward spiral.