NFL Week 6 injury report: Lamar Jackson, Jalen Hurts sidelined; Caleb Williams could return

October 16, 2026

The NFL’s Week 6 injury updates bring a mix of setbacks and potential returns, with two star quarterbacks forced to sit. Baltimore Ravens signal-caller Lamar Jackson will miss his second consecutive game due to an ankle issue, handing the starting role to Tyler Huntley for a second straight week.

Meanwhile, Philadelphia Eagles franchise quarterback Jalen Hurts is out after a blood clot in his calf was diagnosed, leaving backup Tanner McKee to step in for another game. The Eagles’ injury woes extend beyond the quarterback position, with multiple key players sidelined this season, though there’s a glimmer of hope elsewhere.

Michael Penix Jr. has cleared his rib injury and will suit up for the Atlanta Falcons, while Chicago Bears rookie Caleb Williams could make his return this week, adding depth to an offense still adjusting without Justin Fields.

On the defensive side, the Houston Texans’ backfield will rely heavily on backup Woody Marks after David Montgomery was ruled out for the London game, while safety Jalen Pitre’s shoulder injury keeps him off the field. The Jaguars’ secondary faces challenges with cornerback Montaric Brown and long snapper Ross Matiscik out, and Jaylon Jones’ hamstring remains a question mark.