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NFL Week 6 betting: 5 biggest storylines, including Rams still being favored to win Super Bowl

The NFL’s Week 6 betting landscape is shaping up with a mix of surprising favorites and underdogs defying expectations. Despite a shaky 2-3 start—including an overtime loss to the Bills—the Los Angeles Rams remain the top Super Bowl contender in the market, holding +700 odds at multiple sportsbooks.

Their lead in the NFC West has narrowed to three games behind the San Francisco 49ers, but oddsmakers are hesitant to adjust their lines, fearing exposure if the Rams eventually live up to preseason expectations. Meanwhile, the Philadelphia Eagles, who have struggled early with a 2-3 record and a trip to London looming, are still slight favorites (+1) against the Carolina Panthers, who have shown strong offensive play in their 2-2 start.

The week also features a notable number of road teams favored or nearly even, with the Buffalo Bills as the biggest underdog favorite at -7 against the Raiders, adding to the unpredictability of the slate.

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