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Missouri vs Ole Miss Prediction, Odds, Picks Today: College Football Week 7

The Missouri Tigers will look to bounce back from a loss to Mississippi State when they face the Ole Miss Rebels in a key SEC matchup this Saturday. Missouri, led by quarterback Austin Simmons, has shown flashes of brilliance but also struggles with offensive consistency, ranking 94th in havoc allowed and dealing with six sacks already this season.

Their defense, however, remains a bright spot, ranking fourth in havoc generated and excelling in stopping both the run and pass, with Daeden Hopkins and Donta Simpson leading the charge with 112 combined sacks. Ole Miss, meanwhile, boasts a dynamic offense under quarterback Trinidad Chambliss, who is in the Heisman conversation and has the Rebels poised for a strong season.

The Tigers’ recent wins over Florida and Texas A&M, both currently on the decline, raise questions about their ability to handle top-tier competition, especially after their loss to Mississippi State. With Missouri favored as underdogs at +6.5 on the spread and a total of 58.5 points set for the game, the Tigers will need to rely on their stifling defense to pull off the upset against a loaded Rebel offense.

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