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Mississippi State vs LSU Prediction: Odds, expert picks, team and player news, betting trends, and stats
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College Football

Mississippi State vs LSU Prediction: Odds, expert picks, team and player news, betting trends, and stats

October 15, 2026

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The SEC’s top matchup this weekend pits #22 LSU (-600) against #16 Mississippi State (+440) in a high-stakes clash at Tiger Stadium. Both teams enter with recent losses—LSU’s overtime defeat at Kentucky (35-34) and Mississippi State’s blowout loss to Alabama (56-23)—but the Tigers hold a 14.5-point spread advantage.

LSU’s playoff push hinges on this game, while Mississippi State’s offense faces critical questions, particularly with star quarterback Kamari Taylor and running back Fluff Bothwell both questionable due to injuries. Taylor, who has three or more touchdowns in five straight games, has also faced relentless pass-rush pressure, with LSU’s front seven—led by Princewill Umanmielen—posing a formidable challenge.

The Bulldogs’ offensive line, ranked 114th in pass-blocking grades, will be tested immediately, as backup quarterbacks Parker Puckett and AJ Swann lack experience against top-tier defenses. Meanwhile, LSU’s Sam Leavitt (17 total TDs, 9 turnovers) will need to elevate his play to match the Bulldogs’ explosive offense, which has struggled following bye weeks in past seasons (0-5 record, 36.8 PPG allowed).

The game total sits at 56.5, reflecting LSU’s expected dominance if healthy.

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