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The San Francisco 49ers aim to keep their five-game win streak alive when they face the struggling Washington Commanders on *Monday Night Football*, seeking to tighten their grip on the NFC West after Seattle’s loss to Denver. The Commanders enter the match with a lengthy injury list and a 1–1 record, having tied the New York Giants in a physically demanding game.
With their defense allowing just -0.07 expected points added (EPA) per rush attempt—one of the NFL’s stingiest run defenses—Washington’s front seven will be a major obstacle for the 49ers’ ground game, which may need to rely on efficiency rather than volume to overcome them. Meanwhile, the Commanders’ passing defense has been exposed, surrendering 0.05 EPA per pass, while their secondary struggles to contain opposing quarterbacks outside the pocket, a weakness the 49ers will exploit if they can contain Jayden Daniels’ mobility.
Washington’s offensive line, already dealing with the loss of left tackle Laremy Tunsil, has allowed 18 pressures this season, with third-year tackle Brandon Coleman accounting for 32.2% of those—more than any player in the league—raising concerns about durability and protection for Daniels. The 49ers’ secondary, meanwhile, will face its biggest test in limiting Daniels, who thrived in shotgun formations last week against the Giants, rushing for critical yards when Washington’s play-action schemes broke down.
With the Commanders’ receivers also dealing with injuries—including Mike Evans missing practice with Achilles soreness—the 49ers may need to adjust their game plan to minimize turnovers and capitalize on Washington’s defensive vulnerabilities in the passing game.
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