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Week 3 NFL odds, picks, predictions: Computer model backs Lions and 49ers

As the NFL approaches Week 3 of the 2026 season, an advanced predictive algorithm has completed thousands of simulations for upcoming matchups. Notable early fixtures include the Buffalo Chargers game where Buffalo sits as a seven-point favorite, and a Seattle matchup against Washington with the Seahawks similarly favored by seven points.

Washington will play without Jayden Daniels due to an elbow injury, while Sam Darnold is anticipated to return for Seattle. In a historic first, an upcoming contest between Dallas and Baltimore is scheduled to take place in Rio de Janeiro, Brazil, with the Cowboys designated as home underdogs by three and a half points.

The simulation model enters the third week holding a solid historical record on top-rated wagers going back to 2024.