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Week 3 NFL odds, picks, predictions: Computer model backs Lions and 49ers

SportsLine's advanced simulation computer has completed ten thousand runs for every matchup on the Week 3 slate as the 2026 National Football League season progresses. Several games feature significant cross-country travel implications, including Buffalo hosting Los Angeles and Washington welcoming Seattle, where the visitor is favored by seven points despite potential absence concerns for Jayden Daniels.

Meanwhile, an international contest takes place in South America featuring Dallas and Baltimore, marking the historic first league fixture hosted in Rio de Janeiro with the Cowboys listed as three-point underdogs.