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Week 1 NFL odds, picks, predictions: Computer model backs Eagles and Jaguars

5 points against Kansas City and the Giants getting three points versus Dallas in primetime. Another spotlight clash features Atlanta getting six points against Pittsburgh as Aaron Rodgers embarks on his final campaign.

Additionally, a meeting between Las Vegas and Miami stands out as the sole opener showcasing fresh quarterbacks on both sides, with the Dolphins turning to Malik Willis while the Raiders tab Kirk Cousins to start ahead of Fernando Mendoza. Las Vegas enters that contest as a three-point favorite following a 7-10 record against the spread in the previous season.

Ahead of kickoff, SportsLine has evaluated every opening-round fixture by running 10,000 simulations per contest to determine its top selections. Dating back to 2024, the computer simulation platform carries a 53-37 record on high-priority selections and boasts lifetime profits exceeding $7,000 for standard $100 bettors.