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Week 1 NFL odds, picks, predictions: Computer model backs Eagles and Jaguars

Ahead of the 2026 NFL kickoff, SportsLine's predictive algorithm has simulated every Week 1 matchup 10,000 times to generate top betting selections. 5 points against the Kansas City Chiefs and the New York Giants getting 3 points against the Dallas Cowboys.

Bettors will also witness Aaron Rodgers competing in the Pittsburgh Steelers versus Atlanta Falcons game, with Atlanta entering as a 6-point underdog.

Another notable contest features the Miami Dolphins visiting the Las Vegas Raiders, marking the only season-opening fixture where both teams are debuting new starting quarterbacks. Malik Willis takes the reins for Miami against Kirk Cousins, who secured the Raiders' starting role over Fernando Mendoza.

Coming off a 7-10 record against the spread in the previous campaign, Las Vegas is currently favored by a field goal. SportsLine's model brings proven historical success into the new year, riding a 53-37 streak on elite selections since 2024 and producing over $7,000 in overall profit for standard $100 bettors over its lifespan.