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Super Bowl stock report for Week 2: 49ers are healthy and formidable, Chargers dig deeper hole

Following the opening week of the NFL slate, early results are already shifting the championship landscape. The San Francisco 49ers kicked off their campaign with a dominant showing in Australia against the team favored prior to the season, whereas the Los Angeles Chargers began on a sour note by dropping a contest to a club expected to target the top overall draft selection.

Despite navigating absences—with Alfred Collins placed on injured reserve, Mykel Williams sidelined on the physically unable to perform list, and De'Zhaun Stribling anticipated to sit out for at least four weeks—San Francisco boasts significantly better overall health than during the 2025 season. In the latest DraftKings championship odds, the Los Angeles Rams lead the pack at +650, followed by the Baltimore Ravens (+900), Buffalo Bills (+950), and Seattle Seahawks (+1100).

The 49ers and Kansas City Chiefs sit at +1400, leading the Philadelphia Eagles (+1700), Detroit Lions (+1800), Houston Texans (+1900), and Cincinnati Bengals (+1900), with the Chargers, Green Bay Packers, and Denver Broncos rounding out the contenders at +2000.