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Prisco's Week 3 NFL picks: Browns upset Panthers, Giants rally behind Jameis Winston

Analyst Pete Prisco is looking to rebound from a tough Week 2 in which he went 9-7 straight up and 5-10 against the spread, bringing his overall seasonal tallies to 21-11 and 15-17 respectively. Heading into the third week of action, he anticipates a few notable surprises, specifically predicting that Cleveland will defeat Carolina and Tampa Bay will overcome Minnesota.

In other early matchups, Jordan Love and the Packers are projected to handle Michael Penix and the Falcons, Josh Allen and the Bills are favored over Justin Herbert and the Chargers, and Detroit is tipped to edge out the Jets. Additionally, the Texans are expected to secure their initial win of the campaign against the Colts, while the Chiefs are picked to prevail on the road against the Dolphins.