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NFL Week 1 best bets: Big days for star running backs, plus what to expect in Patrick Mahomes' return

September 11, 2026 · CBS Sports

The 2026 NFL campaign is officially underway, bringing a complete slate of projections covering all 16 matchups scheduled for the opening slate. Along with full-slate predictions, the focus centers on major storylines across the league, highlighted by the anticipated on-field comeback of Patrick Mahomes. The initial slate of games is also expected to feature standout performances from several premier running backs looking to make an immediate mark.